细胞粘附分子(研01).ppt

Ig超家族粘附分子01结构：单链，胞外区有Ig样结构02ICAM－1，2，303VCAM－104NCAM05B7-1－CD28，CTLA-4062)CA-INDEPENDENTCAMs(Ig-likeCAMs)membersoftheimmunoglobulinsuperfamilyinvolvedcell-cellnon-junctionaladhesionssingle-passtransmembraneglycoproteinsmanyisoforms,weakerinteractions,changesofN-CAMexpressionindevelopmentN-CAMs:mostlyhomophilic(NeuralCAM)I-CAMs:heterophilic(IntercellularCAMs(onactivatedendothelialcells)theextracellularside:5Ig-likerepeatsand1-2fibronectin(typeIII)repeatsvariousextentofglycosylationthecytoplasmicside:variable,involvedincellsignalling,bindstothecytoskel.,toGPIorsecretednoadhesionplaques(?)EC等TNF，Mac-1ICAM-1激活IL－1，WBC上的LFA-1ICAM-2EC等WBC上的LFA-1IFNrVCAM-1激活IL－1,Mono上的VLA-4ECTNFLymph上的VLA-4分布刺激物整合素配体作用：与整合素一起，参与免疫、炎症01反应，传递淋巴细胞的共刺激信号。02使淋巴细胞激活的信号：03抗原信号：第一信号04共刺激信号（第二信号）：由粘附分子介05导的信号。06B7-1－CD28，CTLA-407选择素家族（Selectin）01识别SLex的lectin(凝集素)的粘附分子。02单链，一次跨膜，胞外区从N端起依次为凝集素样区、表皮生长因子（EGF）样区和数个补体结合区。03配体为寡糖Slex、Slea等。04”Majorfamiliesofcelladhesionproteins.CadherinarehomophilicadhesionmoleculesIg-superfamilyareCa2+independentandparticipateinheterophilicandhomophilic.SelectinsbindcarbohydrategroupsonadjacentcellsonlyinthepresenceofCa2+Hynes:TiCB:9:M331999CadherinsCa2+-dep.homophilicadhesionfunctionalunit=dimerImmunoglobinsuperfamily(CAMs)homophilicorheterophilicSelectinsheterophilicPselectin+counter-receptorPSGL-1,glycosylatedIntegrinsheterodimers,heterophilicbindtoECM,Ig-CAMs,cadherinsadhesion,polarity,migrationCadh.repeatsIgandFnIIIrepeatslectinrepeatsI-CAMCELLADHESIONMOLECULESCELL-CELLadhesion组成：L–Selectin在各型leukocyte组成性表达；E-Selectin(ELAM-1)表达于活化的