养心开郁片治疗中、轻度抑郁症90例临床观察.pdfVIP

养心开郁片治疗中、轻度抑郁症90例临床观察--第1页

养心开郁片治疗中、轻度抑郁症90例临床观察

林海;王静怡;王晓燕;王开娜;刘岗;吕富荣;杨琳;查鹏洲

【摘要】Objectives:ToobserveefficacyandsafetyofYangxinKaiyutablets

onmoderateormilddepression.Method:135patientswererandomized

tothetabletarm(n=90,4tablets,3timesperday)andFluoxetinearm

(n=45,25mg/dayinthemorning);backgroundmedication:4Zaoan

capsules30minbeforebed.Efficacyandsafetyparametersincludethe

Hamiltondepressionratingscale(HAMD-17),TCMsyndromscale,

SymptomChecklist90(SCL-90),self-ratingscalefordepression(SDS),

self-ratingscaleforAnxiety(SAS),RatingScaleforSideEffects(SERS)

andrelatedlaboratoryanalysisatWEEK2andWEEK6.Results:Therewere

nostatisticalsignificanceofbeforetreatment(P＞0.05).AtWEEK2both

groupsimprovedonallparameters(P＜0.05);AtWEEK6totaleffective

rateforthetabletwas85.55％.Thetotaleffectiverateandthescoresof

variousratingscaleatthesettimepointswerenotstatisticallydifferent

betweenthetwogroups.TheSASassessmentwasbetterwiththetablet.

Palpitation,insomniaandthesymptomofdepressionimproved

significantlyinthetreatmentgroupandthecontrolgrouprespectively(P

＜0.05).Nosafetyconcernsrevealedduringthestudy.Conclusion:the

YangxinKaiyutabletscantreatmoderateormilddepressionwithout

obvioussafetyissue.%目的:观察养心开郁片治疗中-轻度抑郁症的临床疗效及安

全性.方法:将135例患者随机分为治疗组90例,对照组45例,治疗组口服养心开郁

片4片/次,3次/d;对照组口服氟西汀25mg/d,上午服用;夜间睡前30min2组均给

养心开郁片治疗中、轻度抑郁症90例临床观察--第1页

养心开郁片治疗中、轻度抑郁症90例临床观察--第2页

予枣安胶囊2～4粒.于第一次就诊及用药第2和6周末分别以HAMD-17、中医

症状量表、SCL-90、SDS、SAS、SERS量表及实验室检查评估疗效与安全性.结果:

用药前2组各类量表评分无统计学差异(P0.05);用药2周后治疗组各类评分均有

所改善(P0.0