μ阿片受体 A118G 基因多态性预测盐酸羟考酮的镇痛效果.pdfVIP

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μ阿片受体A118G基因多态性预测盐酸羟考酮的镇痛效果

李擎;刘勇;于洋;王燕

【摘要】ObjectiveToexaminetherelationshipbetweentheA118G

polymorphismofmu-opioidreceptor(OPRM1)geneandanalgesiceffects

ofoxycodonehydrochlorideinpatientswithseverecancerpain.Methods

Fifty-ninepatientswithseverecancer-inducedpainweredividedinto3

groupsbygenotype(AAgroup,AGgroupandGGgroup,23,28,8patients,

respectively).Theywereorallytreatedwithoxycodonehydrochloride

sustained-releasetablets,andthetreatmentdosageandadverse

reactions(includingnausea,vomiting,dizziness,constipation,etc.)were

comparedbetweengroups.ResultsThevariationofallele

frequencies(118G)was37.3%.Thedosageofoxycodonehydrochloride

sustained-releasetabletsusedinAA,AGandGGgroups

was(27.0±14.3),(36.4±22.5)and(55.0±35.1)mg,respectively,andthe

differenceswerestatisticallysignificantbetweengroups(P=0.01).Onthe

partofadversereactions,theincidenceofnauseaandvomiting,dizziness,

constipationwas28.8%,22.0%,and52.5%,inAA,AGandGG

groups,respectively,andtherewasnosignificantdifferencebetween

groups(P0.05).ConclusionTheanalgesiceffectofoxycodone

hydrochlorideisaffectedbyopioidreceptorgenepolymorphism.Patients

withGallelicvariation(AGorGGgenotype)requirelargerdosesof

oxycodonehydrochloridethanthosewithAAgenotype.However,adverse

reactionsarenotassociatedwithpolymorphism.%目的：探讨μ阿片受体

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（OPRMl）A118G基因多态性与盐酸羟考酮治疗癌痛效果的关系。方法重度癌痛

患者59例，根据基因型的不同分为野生型纯合子（AA）组23例，突变型杂合子

（AG）组28例，突变型纯合子（GG）组8例，分别口服盐酸羟考酮缓释片，比

较治疗用量，记录相关的不良反应（包括恶心呕吐、眩晕、便秘等）。结果变异的

等位基因频率（118G）为37.3%，AA组、AG