高血压与血管损伤_高平进.ppt

Hypertensionandvascularinjury

高血压与血管损伤;Vascularinjuryisdefinedbyfunctionalandstructuralalterationoflargeandsmallvascularinducedbyhighbloodpressure.;THEVASCULARTREE;VascularinjuriesinHypertension;Ourapproach;PartI;ThechangeofVascularstructureandfunctioninhypertension;Stress–strainrelationshipoftheaorta;胶原和弹性蛋白在血管的分布;胶原和弹性蛋白变化;相关性分析:血管结构与脉压的关系;Vascularfunctioninhypertensiverats;SBP与PWV：R=0.777,p0.001;Themechanismofabnormalstructureinvascularwall;EffectofAngIIoncollagensynthesisandexpression;AngII-inducedROSformation;EffectofROSonAngII-inducedcollagenexpression;

;InflammatorymediatorsmRNAexpressionconfirmedbyReal-timePCR;Inflammatorymediatorsproteinexpressionorsecretion;Effectoftreatmentonvascularstructureandfunction;Losartan和Spironolactone

—血管壁组织干重;Losartan和Spironolactone--胶原含量;Losartan和Spironolactone--弹性蛋白;PWV;PWV;PartII;Non-invasiveexaminationofvascularstructureandfunction;SBP;CorrelationbetweenPWVandAASI;ThedecreaseofAASI(ΔAASI)was

significantlyassociatedwith

thereductionofSBP(ΔSBP)

andpulsepressure(ΔPP),

evenafteradjustingforage,

gender,height,baseline24-hBP,PP,andheartrate(HR),

nocturnalBPfall.;0.44;颈总动脉IMT，本研究中应用PHILIPSHD11EX超声仪提供的Qlab软件自动测量，IMT0.9mm定义为增厚，IMT1.3mm定义为斑块形成。图a为正常颈总动脉IMT；图b为颈总动脉IMT增厚；图c为颈总动脉粥样硬化斑块形成（箭头所示）。;基础状态下肱动脉直径图;;CorrelationofFMDwithtargetorgandamage(TOD);Characteristics;Numberoftargetorgandamage(TOD)andtheseverityofFMD; TheseverityofFMDandTOD

;TofindtheBio-markersforpredictorvascularinjuryinhypertension;TGF-b1ANGII;高血压组与正常对照组一般资料的比较(±s);高血压组与正常对照组血清OPN与hs-CRP浓度的比较(±s);血清hs-CRP与OPN的相关性;Ln(hs-CRP)、OPN与多种危险因素的相关性分析;各种相关因素的工作特征(ROC)曲线下面积比较;相关因素的Logistic逐步回归分析;MMP-2、MMP-9、TIMP-1levelsbetweenhypertensivesandnormotensives;MMP-2,MMP-9,TIMP-1,OPNandCRPbetweenCKDgroupsinhypertensivepatients;;DingliangZHU,PROF.

YiZHANG,AssociatePR