Skin皮肤专题知识讲座.pptx

TheskinandSkinRegenerativeMedicine第1页

KayiName?第2页

第3页

Agingskin第4页

skin

thelargestorganinthebodyprotectsenseregulatetemperatureProductionofVitaminDClininiansDermatology-----dermatologistPlasticandestheticsurgery------plasticsurgeon第5页

Keratinocytefibroblast第6页

OBJECTIVEMasterskinstructureandfunctionepidermis-----keratinization:proliferation/differentiationAcquaitanceAnomaliesofskin----commonskindiseasesAdvanceSkinregenerativemedicine第7页

INTRODUCTIONepidermisdermishypodermis第8页

DermisPapillarylayer+Reticularlayer第二节真皮第9页

skindermis真皮papillarylayer乳头层reticularlayer网织层appendages附属器hair毛sebaceousgland皮脂腺sweatgland汗腺THESTRUCTUREOFSKINepidermis表皮stratumcorneum角质层stratumlucidum(透明层)stratumgranulosum颗粒层stratumspinosum棘层stratumbasale基底层nail指(趾)甲第10页

EPIDERMIS重要细胞构成keratinocyte(角质形成细胞)non-keratinocyte(非角质形成细胞)differentiationstratumcorneum角质层stratumgranulosum颗粒层stratumlucidum(透明层)stratificationstratumbasale基底层stratumspinosum棘层第11页

（一）Epidermalstratificationanddifferentiation第12页

PSORIASIS银屑病redandwhitehuesofscalypatchesappearingonthetopfirstlayeroftheepidermis(skin).第13页

Langerhanscell(郞格汉斯细胞)Langerhanscellsaredendriticcells(antigen-presentingimmunecells)oftheskinandmucosa,andcontainlargegranulescalledBirbeckgranules.Theyarepresentinalllayersoftheepidermis,butaremostprominentinthestratumspinosum.Inskininfections,thelocalLangerhanscellstakeupandprocessmicrobialantigenstobecomefullyfunctionalantigen-presentingcells.LangerhanscellsderivefromthecellulardifferentiationofmonocyteswiththemarkerGr-1(alsoknownasLy-6G/Ly-6C).Thisdifferentiationrequiresstimulationbycolonystimulatingfactor(CSF)-1.6Theyaresimilarinmorphologyandfunctiontomacrophages.第14页

Albinoslackanenzymecalledtyrosinase.Tyrosinaseisrequiredformelanocyt