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MonocytesandmacrophagesAfterenteringintotissue,monocytesdifferentiateintotissuemacrophages.Playcentralrolesininnateandadaptiveimmunity,andareimportanteffectorcellsfortheeliminationofmicrobes.Functions:phagocytosis,intracellularandextra-cellularkilling,tissuerepair,antigenpresentationMonocytesandmacrophagesmacrophagesEosinophilscytoplasmicgranulesthatareeasilystainedbyeosinorotheraciddyes.associatedwithparasiticinfectionandallergicreactions.Basophilscytoplasmicgranulesthatareeasilystainedbybasicdyes.associatedwithparasiticinfectionsandallergicreactions.TandBLymphocytesNaturalKiller(NK)cellsalsoknownaslargegranularlymphocytes(LGL)killinfectedandmalignantcellsAntibodyComplementsCytokinesMoleculesAntibodyImmunoglobulinPlasmacellNeutralizationClassesofIgIgG;IgA;IgM;IgE;IgDComplementsystemcytokinesecretedproteinsthatworkasmediatorsofimmuneandinflammatoryreactions.Cytokinesprovideamechanismforcellsoftheimmunesystemto“talk”tooneanothertocoordinatearesponseHowdoestheimmunesystemwork?InnateandadaptiveimmunityFirstlineofdefense(nonspecific)secondlineofdefenseTheskinisanimportantphysicalbarrierthatprotectstheentirebodyfromexternalpathogens.Theacidinthestomachservesasanaturalkillerordestroyerofpathogensthatenterthedigestivetract.circulatingcells(phagocytes，NKcells)bloodproteinsandcytokinesBarriersinnateimmunityInnateandadaptiveimmunityAdaptiveimmunity3Phases,2TypesSpecificacquired①Recognition②Activation③EffectorHumoralimmunityCell-mediatedimmunityInnateandAdaptiveImmunityVaccines:1880,chickencholera1881,anthrax1885,rabiesconsciouslyimmunesystemWhatisit?Whereisit?Howdoesitwork?Whatisimmunity?immunityImmunesystemImmuneresponseImmunologyImmunologistImmunodeficiencyImmunocompromisedIMMUNITY←←IMMUNI
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