细胞癌变及诱导因素徐单单Cellularcarcinogenesisandinducingfact.pptx

细胞癌变及诱导因素主讲老师：徐单单CellularcarcinogenesisandinducingfactorsGuangdongFoodandDrugVocationalCollege广东食品药品职业学院

肿瘤概述01TumorOverview细胞恶性转化及诱导因素02Malignanttransformationofcellsandinducingfactors

01肿瘤概述TumorOverview

肿瘤概述TumorOverview癌症已成为人类健康的第一大杀手，每年全世界新出现的癌症病例为500-700万，中国为180-200万。Cancerhasbecomethenumberonekillerofhumanhealth,with5-7millionnewcancercasesworldwideeachyear,and1.8-2millioninChina

肿瘤：是机体遗传和环境因素以协同或序贯的方式，引起遗传物质DNA损伤、突变，同时伴随有多个癌基因激活和肿瘤抑制基因失活，使正常细胞不断增生、转化形成新的生成物，常表现为局部肿块。Tumor:Itiscausedbythesynergisticorsequentialcombinationofgeneticandenvironmentalfactorsinthebody,resultinginDNAdamageandmutationofgeneticmaterial,accompaniedbyactivationofmultipleoncogenesandinactivationoftumorsuppressorgenes,causingnormalcellstocontinuouslyproliferateandtransformintonewproducts,oftenmanifestedaslocaltumors.

肿瘤细胞具有异常的形态、代谢和功能。Tumorcellshaveabnormalmorphology,metabolism,andfunction.它生长旺盛，常持续生长。Itgrowsvigorouslyandoftencontinuestogrow

肿瘤的发生是一个长期的、多阶段、多基因改变累计的过程，具有多基因控制和多因素调节的复杂性。Theoccurrenceoftumorsisalong-term,multi-stage,andmultigeneaccumulationprocess,withthecomplexityofmultigenecontrolandmultifactorregulation.良性肿瘤Benigntumors恶性肿瘤Malignanttumors

02细胞恶性转化及诱导因素Malignanttransformationofcellsandinducingfactors

细胞恶性转化及诱导因素Malignanttransformationofcellsandinducingfactors肿瘤是一种细胞病，肿瘤发生的本质是细胞的遗传物质——基因组DNA，所携带的遗传信息发生病理改变而造成的细胞病，亦即由于多基因内的结构或功能改变的积累而导致细胞的增值失控和分化异常，以致细胞突变获得两种基本特性：Tumorisacellulardisease,andtheessenceoftumoroccurrenceisthepathologicalchangesinthegeneticinformationcarriedbythegeneticmaterialofcells-genomicDNA.Thisiscausedbytheaccumulationofstructuralorfunctionalchangesinmultiplegenes,leadingtouncontrolledproliferationandabnormaldifferentiationofcells,resultinginmutantcellsacquiringtwobasiccharacteristics：肿瘤是什么样的疾病？Whatkindofdiseaseisatumor?

以上两个特征相结合造成肿瘤细胞的转移、播散。肿瘤