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Migraine偏头痛(中英双语版).ppt

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migraine

偏头痛

ChongqingUniversityofMedicalScience

Migraineismanifestedbyheadachethatis

arecurrence,usuallyunilateralandfrequently

pulsatileinquality搏动性;itisoftenassociated

withnausea,vomiting,photophobia畏光,

phonophobia惧声andlassitude乏力.Visualor

otherneurologicauras神经学先兆occurinabout

10%ofpatients.

Theonsetisearlyinlifeapproximately25%

beginningduringthefirstdecade,55%by20

yearsofage,morethan90%beforeage40.

A.Causeandpathogenesis

Therealcausesandthepathogenesisand

pathophysiologiccourseofmigraineisunknown.

1.Certainfoods:tyramine酪胺-containing

cheeses,meat,suchashotdogsorbacon,with

nitrite亚硝酸preservatives,chocolatecontaining

butnotchocolatealone.Foodadditives:

monosodiumglutamate谷氨酸一钠;

Fasting禁食;Emotion情绪;Menses月经;

Drugs:especiallyoralcontraceptiveagents;

vasodilators(nitriglycerin硝酸甘油)

Brightslightsmayalsotriggerorprecipitate

attacks.

2.Genetics:About60%patientsofmigraine

havefamilies.Threegeneticlociforfamilial

hemiplegicmigraine(偏瘫型)havebeenidentified

3.Endocrinefactor内分泌异常

Gender:womenmen(2/3to3/4ofcases

occurinwomen);Headachemostlyoccurs

beforeormenacme月经期inwomen,andthe

headachebecomesreductionorstoppinginpregnancyandaftermenopause绝经.

Themigrainealsostopsinmenofafterclimacterium更年期.

4.vasomotorandautonomic血管运动和自律神经

Intracranialvasoconstrictionandextracranial

vasodilatationhavelongbeenheldtobethe

respectivecausesoftheauraandheadache

phasesofmigraine.ButthestudyofCBF脑血流

can’tconfirm.

5.spreadingdepression扩布性抑制

MorerecentstudiesofrCBF局部脑血流during

migraineattackshavedemonstratedareduction

inregionalflow,whichbeginsintheoccipital

regionandthentowardswith1cm/svelocit

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