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運用微晶片篩選癌症基因和探討其上游之調控microRNAs
ContentsMotivationPredictcancergenesbasedonmicroarraymRNAexpressionlevelsmicroRNA(miRNA)canactasanoncogene(OCG)ortumorsuppressorgene(TSG)Identifycancer-relatedmiRNAs,theirtargetgenes,downstreamprotein-proteininteractions(predictionnovelcancerousproteins)(1) Introduction–microarray,cancer,microRNA(2) Methods–inputdata(3) Results (a)cancergenesprediction(Bioconductor),i.e.prostate/breastcancer (b)correlationstudyofmiRNAsandmRNAexpressionlevels (c)ncRNAppi–AplatformforstudyingmicroRNAandtheirtargetgenes’protein-proteininteractions(4) Summary
CentraldogmaofmolecularbiologyPost-transcriptionregulation–microRNAtargetsmRNAtranscriptome
TypesofRNAsRNAmRNAncRNANon-codingRNA.TranscribedRNAwithastructural,functionalorcatalyticrolerRNARibosomalRNAParticipateinproteinsynthesistRNATransferRNAInterfacebetweenmRNAaminoacidssnRNASmallnuclearRNAIncl.RNAthatformpartofthespliceosomesnoRNASmallnucleolarRNAFoundinnucleolus,involvedinmodificationofrRNAmiRNAMicroRNASmallRNAinvolvedregulationofexpressionOtherIncludinglargeRNAwithrolesinchromotinstructureandimprintingsiRNASmallinterferingRNAActivemoleculesinRNAinterferencestRNASmalltemporalRNA.RNAwitharoleindevelopmentaltimingIntroduction
癌症的形成及
97年台灣前十大主要癌症死亡原因摘要順位死亡原因CauseofDeath死亡數百分率癌症類型CancerType38,913100%1肺癌LungCancer7,77720.0%2肝癌HepatocellularCarcinoma7,65119.7%3結腸直腸癌ColorectalCancer4,26611.0%4女性乳癌FemaleBreastCancer1,5414.0%5胃癌GastricCancer2,2925.9%6口腔癌OralCavityCancer2,2185.7%7前列腺(攝護腺)癌ProstateCancer8922.3%8子宮頸癌CervicalCancer7101.8%9食道癌EsophagealCancer1,4333.7%10胰臟癌PancreaticCancer1,3643.5%
ByHanneJarmer,BioCentrum-DTU,TechnicalUniversityofDenmarkcDNAlabeledbyCy3(Green)cDNAlabeledbyCy5(Red)ProbegenesTargetMicroarray–overview
Microarraysareusedtomeasuregeneexpressionlevelsintwodifferentcon
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