perfusion for selecting patients with acute ischemic stroke intravenous thrombolytic therapy用于选择急性缺血性卒中患者灌注静脉溶栓治疗.pdfVIP

PerfusionCTforSelectingPatientswithAcuteIschemic

StrokeforIntravenousThrombolyticTherapy

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KirsteenR.Burton,MBA,MSc,MD,

DeljitDhanoa,MD,

RichardI.Aviv,MBChB,

AlanR.Moody,MBBS,

MoiraK.Kapral,MD,MSc,

AndreasLaupacis,MD,MSc

FromtheInstituteforHealth,ManagementandEvaluation(K.R.B.,M.K.K.,A.L.),Departmentof

MedicalImaging(K.R.B.,R.I.A.,A.R.M.),InstituteofMedicalSciences(R.I.A.,A.R.M.),andDepartment

ofMedicine(M.K.K.,A.L.),UniversityofToronto,263McCaulSt,4thFloor,Toronto,ON,C5T

1W7;DepartmentofMedicalImaging,FraserHealthAuthority,Vancouver,BritishColumbia,Canada

(D.D.);DepartmentofMedicalImaging,UniversityofBritishColumbia,Vancouver,BritishColumbia,

Canada(D.D.);InstituteforClinicalEvaluativeSciences,Toronto,Ontario,C.K.K.);andLiKa

ShingKnowledgeInstitute,St.Michael’sHospital,Toronto,Ontario,Canada(A.L.).

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Introduction

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Strokeisacommondiseasethatproducessubstantiallong-termhealthandeconomicburdens(1–3).In

Canada,theannualcostofcarewithinthe1st6monthsofstrokeisestimatedat$2.5billionCanadian(4).

Acuteischemicstroke(AIS)constitutesapproximately85%ofallstrokes,withoptimalmanagement

requiringtimelyaccesstoneuroimaging(computedtomography[CT]oricreson