CNI103-生命科学试剂-MCE.pdf

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CNI103

Cat.No.:HY-P10889

CASNo.:2366279-86-7

分⼦式:C₁₁₆H₁₈₀Cl₂N₃₆O₂₆

分⼦量:2565.8

Sequence:{Dcn}-{Tle}-Ile-{Hva}-Ile-Thr-Gln-His-{d-Leu}-Ser-{miniPEG}-Ly

s-{CPP9}

SequenceShortening:{Dcn}-{Tle}-I-{Hva}-ITQH-{d-Leu}-S-{miniPEG}-K-{CPP9}

作⽤靶点:Phosphatase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CNI103是⼀种⾼效的和代谢稳定的钙调磷酸酶的细胞通透性肽(cell-permeablepeptide)抑制剂。CNI103可

以选择性阻断钙调神经磷酸酶和NFATc3之间的相互作⽤(KD=16nM)，从⽽阻⽌体外和体内NFATc3的激活

。CNI103可⽤于急性呼吸窘迫综合征(ARDS)和其他炎症性疾病的研究。

REFERENCES

[1].DoughertyPG,etal.APeptidylInhibitorthatBlocksCalcineurin-NFATInteractionandPreventsAcuteLungInjury.JMedChem.2020

Nov12;63(21):12853-12872.

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