Kalafungin-Kalamycin-生命科学试剂-MCE.pdf

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Kalafungin

Cat.No.:HY-105751

CASNo.:11048-15-0

Synonyms:Kalamycin;U-19718

分⼦式:C₁₆H₁₂O₆

分⼦量:300.26

作⽤靶点:Antibiotic;Bacterial;Beta-lactamase;Fungal

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Kalafungin是⼀种来⾃海洋链霉菌的抗⽣素、抗菌剂和β-lactamase抑制剂，其IC50值为225.37μM。

Kalafungin能破坏细胞膜。Kalafungin对多种致病真菌、酵母菌、原⽣动物、⾰兰⽒阳性细菌(如⾦黄⾊葡萄

球菌ATCC33591和⾦黄⾊葡萄球菌ATCC23591)具有抑制作⽤，对⾰兰⽒阴性细菌的抑制作⽤较弱[1][2]。

REFERENCES

[1].JabilaMaryTR,etal.β-lactamaseinhibitorypotentialofkalafunginfrommarineStreptomycesinStaphylococcusaureusinfected

zebrafish.MicrobiolRes.2021Mar;244:126666.

[2].JohnsonLE,etal.Kalafungin,anewantibioticproducedbyStreptomycestanashiensisstrainKala.ApplMicrobiol.1968

Dec;16(12):1815-21.

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