普外科医生病理课件.ppt

普外科医生病理mesenchymal：间叶

interstitial：间质

Stroma:基质四个阶段八十年代以前的平滑肌瘤与平滑肌肉瘤八十年代的胃肠道间质瘤(gastrointestinalstromaltumor，GIST)九十年代初的胃肠道自主神经肿瘤（gastrointestinalautonomicnervetumor，GANT）)九十年代末的胃肠道起搏细胞肿瘤(gastrointesinalpacemakercelltumors，GIPACT)格列卫（Glivec，STI571）普外科医生病理普外科医生病理普外科医生病理普外科医生病理普外科医生病理*indiscernible[,indis?:n?bl]adj.1.difficultorimpossibletoperceiveordiscernanindiscernibleincreaseintemperature2.barelyabletobeperceivedthetransitionwasalmostindiscernibleindiscernible[,indis?:n?bl]adj.不可识别的，难以觉察的，难以辨别的；觉察不出的n.不可识别的事物；无法辨认的事物1难识别的2察觉不出3分辨不清的*TheInterstitialcellofCajal(ICC)isatypeofcellfoundinthegastrointestinaltract.Itservesasapacemakerthattriggersgutcontraction.[1]ManytypesofsmoothmuscletissueshavenowbeenshowntocontainICC,butwithfewexceptionsthefunctionofthesecellsisnotknownandiscurrentlyanareaofactiveresearch.Aninternationalsociety(InternationalSocietyforICC,)hasrecentlybeenformedtoprovideaforumtodiscussresearchinICCinavarietyoftissues.SantiagoRamónyCajal(1May1852–17October1934)wasaSpanishhistologist,physician,pathologistandNobellaureate.Hispioneeringinvestigationsofthemicroscopicstructureofthebrainweresooriginalandinfluentialthatheisconsideredbymanytobethegreatestneuroscientistofalltime.[1]Hisskillsasanartistallowedhimtomakehundredsofdrawingssobeautifulandlucidthatmanyofthemarestillusedforeducationalpurposestoday.[2]*C-kitFour-μmthicksectionswerepreparedfromtwoparaffinblockstakenfromthedissectedfragments.Oneblockwasusedforhematoxylinandeosin(HE)stainingandfordetailedhistologicalexaminationandtheotherwasusedforimmunohistochemistry(11-12).Afterblockingendogenousperoxidaseactivitywith3%hydrogenperoxidaseinmethanol,sectionswereincubatedfor40minforantigenretrieval.Aftertreatmentwith