HER2-targeted-peptide-H6F-生命科学试剂-MCE.pdf

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HER2-targetedpeptideH6F

Cat.No.:HY-P10792

CASNo.:1644155-35-0

分⼦式:C₅₈H₇₇N₁₁O₁₂

分⼦量:1120.3

Sequence:Tyr-Leu-Phe-Phe-Val-Phe-Glu-Arg

SequenceShortening:YLFFVFER

作⽤靶点:EGFR

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性HER2-targetedpeptideH6F是⼀种HER2靶向肽，通过与HER2结合靶向乳腺癌细胞，氨基酸序列为

YLFFVFER。HER2-targetedpeptideH6F能够与双功能螯合剂⽔杨酰胺(HYNIC)偶联，⽤于与99mTc结合进

⾏放射性标记。单光⼦发射计算机断层扫描(SPECT)成像显⽰，标记后的HER2-targetedpeptideH6F能够特

异性地在HER2阳性的MDA-MBA-453肿瘤⼩⿏模型中积累。HER2-targetedpeptideH6F可⽤于肿瘤分⼦影像

学研究[1]。

IC50TargetHER2

REFERENCES

[1].OkarviSM,etal.DevelopmentoftheTumor-SpecificAntigen-DerivedSyntheticPeptidesasPotentialCandidatesforTargetingBreast

andOtherPossibleHumanCarcinomas.Molecules.2019Aug29;24(17):3142.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.