Apelin-13通过调控巨噬细胞极化改善心肌缺血_再灌注损伤.pdfVIP

目录

中文摘要·········································································································1

英文摘要·········································································································4

英文缩写········································································································8

研究论文Apelin-13通过调控巨噬细胞极化改善心肌缺血/再灌注损伤

前言········································································································10

材料与方法···························································································12

结果········································································································24

讨论········································································································36

结论········································································································38

参考文献································································································38

综述炎症反应在心肌缺血再灌注损伤中的研究进展·····························44

致谢················································································································57

个人简历········································································································58

中文摘要

Apelin-13通过调控巨噬细胞极化改善心肌缺血/再灌

注损伤

摘要

目的：Apelin最初是从牛胃组织分泌物中提取出的肽激素，是A

类（视紫红质样）G蛋白偶联受体（GProtein-CoupledReceptor,

GPCR）APJ的内源性配体。Apelin/APJ系统在各种组织中广泛表达，

例如心脏、血管、肺、肾脏和脂肪组织等，近些年来其在心血管疾病

方面的研究较为突出，Apelin通过受体APJ使血管平滑肌舒张，具有

降压作用；它还可以促进心肌细胞收缩，增强心肌梗死后心肌细胞的

收缩力，Apelin的这种作用可能与调节细胞内Ca2+浓度有关。此外，

Apelin可以增强离体心肌的收缩力，且呈剂量依赖性，被认为是最强

的内源性强心物质之一。心肌梗死患者入院时Apelin水平降低与心

肌缺血状态呈正相关，因此Apelin可能作为一种内源性代偿机制来

平衡心肌缺血急性期的交感神经活动，从而起到心脏保护作用。为了

进一步了解Apelin