any difference on efficacy and toxicity between east west东西方之间疗效毒性任何差异.pptx

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any difference on efficacy and toxicity between east west东西方之间疗效毒性任何差异.pptx

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AnyDifferenceonEfficacyandToxicityBetweenEastandWestJieHuZhongshanHospital,FudanUniversityShanghaiRespiratoryResearchInstituteShanghai,ChinaJieHu,ZhongshanHospital,China

DISCLOSURESNoDisclosures

IncidenceandMortalityofLungCancerintheWorldwideAdaptedfromGLOBANCAN2018Incidence,bothsexesMortality,bothsexes5-yearprevalence,bothsexesIntheEasternAsia~950,015newcasesoflungcancerin2018and815,635predicteddeathsin2018IntheNorthAmerica~252,746newcasesoflungcancerand~173,278deathsin2018

AdaptedfromGLOBANCAN2018IncidenceandMortalityofLungCancerintheWorldwide

Multivariable-adjustedoverallsurvivalbyethnicgroupinthetotalpopulation.J.M.Varlottoetal.CancerMedicine2018;7(4):12112012,retrospectivereviewoftheSEER,N=153,027TheChinesewerepresentedwiththehighestpercentageofadenocarcinomas(69.4%),WhiteswerepresentedwiththehigherpercentageofStageIdisease(23.4%)AscomparedtotheWhitepopulation,OSweresignificantlygreaterintheChinese,SouthAsians,otherAsians,WhiteshadalowerOSthanallraces(HR=0.705–0.977)Population-baseddifferencesinOSoflungcancerbaseduponracial

Anydifferencebetweeneastandwest?

EfficacyandToxicityAnydifferencebetweeneastandwest?ExtrinsicdietaryhabitstobaccoandalcoholconsumptionEnvironmentalpollutionsocioeconomicstatusattitudetothemanagementofmalignanciesandtreatmentcomplianceIntrinsicgeneticpolymorphismsgeneexpressiongenemutationsage,gender,end-organfunction,leanbodymassandbodycompositionJ.Clin.Oncol.20(18Suppl.),S47–S59(2002)ChemoTarget、ICIs

Let’sstartfromChemoeraGenerally,therewasnotmuchdifferenceinefficacyandtoxicitybetweeneastandwestExceptfor…

PKandtoxicityanalysis—Samedrug,differentdoseandtoleranceNoracialdifferenceintheeliminationofDocetaxel1DocetaxelshowedhigherincidenceofG3-4neutropeniainAs