003.盐酸法舒地尔注射液与6种溶液配伍的择优选择.pdf

盐酸法舒地尔注射液与6种溶液配伍的择优选择

与摘要]目的考察盐酸法舒地尔注射液种溶媒配伍稳定性方法将盐酸

法舒地尔注射液分别加入到500mL的5%葡萄糖注射液，10%葡萄糖注射液，0.9%

氯化钠注射液，5%/0.9%葡萄糖氯化钠注射液，工50mL的5%木糖醇注射液及复方氨

基酸注射液18AA中，放置工4h，测定室温工5℃静置下1工左456

工4h时间点盐酸法舒地尔的含及pH值采用高效液相色谱法测定盐酸法

结果

舒地尔含，6种同溶媒的盐酸法舒地尔注射液在工4h内含pH值均稳定，外

观性状无变化，中放置含稳定性最高的是5%的木糖醇溶液和0.9%的氯化钠溶

液，最低的是复方氨基酸注射液18AA结论6种溶液在6h内基本稳定

单纯性急性脑梗死患者，配置药品后立即使用或使用过程长的患者建议选用氯

化钠溶液盐酸法舒地尔配伍使用，糖尿病患者建议使用木糖醇配伍，高血压患

者建议使用葡萄糖配伍

与关键词]静脉用药调配中心盐酸法舒地尔注射液配伍稳定性

FasudilHydrochlorideInjectionto6kindsofsolutionforcompatibilityofthe

optimalchoice

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ZHAOYing-ru,ZHOUWei,QUXiao-yu,SONGYan-qing,ZHANGSi-xiThefirst

hospitalofjilinuniversitymedicinedivision,jilinChangchun130012,China)

[Abstract]Objective:FasudilHydrochlorideInjectionand6kindsofsolvent

compatibilitystability.Methods:WillFasudilHydrochlorideInjectionwereaddedto

500mLof5%glucoseInjection,10%glucoseInjectionand0.9%sodiumchloride

Injection,5%/0.9%glucoseandsodiumchlorideInjection,250mLof5%xylitol

InjectionandcompoundaminoacidInjection(18AA),24h,measuredatroom

temperature(25℃)underletstand1,2,3,4,5,6and24htimepointofhydrochloric

acidmethod,contentandpHvalue.Results:FasudilHydrochlorideInjectionby

HPLCdeterminationofhydrochloricacidmethod,content,sixdifferentsolventof

hydrochloricacidmethod,FasudilHydrochlorideInjectioninjectionwithin工4h

cont刘ntan列pHstability,app刘aranc刘nochang刘,on刘ofth刘high刘stplac刘列

cont刘ntstabilityis5%ofxylitolsolutionand0.9%sodiumchloridesolution,

compoundaminoacidinjection(18AA)arethelowest.Conclusion:With6kindsof

solutionwithin6hbasicallysta