老年胃溃疡患者经益生菌联合抗Hp方案治疗的可行性及对肠道菌群分布的影响研究.pdf

·112·中国实用医药2024年7月第19卷第13期ChinaPracMed,Jul2024,Vol.19,No.13

老年胃溃疡患者经益生菌联合抗Hp方案治疗的

可行性及对肠道菌群分布的影响研究

陈名郭霞

【摘要】目的探究益生菌联合抗幽门螺杆菌(Hp)方案治疗老年胃溃疡患者的可行性及对肠道菌

群分布的影响。方法60例老年胃溃疡患者,采用计算机随机分组为观察组和对照组,每组30例。观

察组患者经益生菌联合抗Hp方案治疗,对照组患者应用抗Hp方案治疗。比较两组患者的肠道菌群分布、

不良反应发生率和复发率。结果治疗前,两组患者肠杆菌、酵母菌以及双歧杆菌比较,差异无统计学

意义(P0.05)；观察组患者治疗14d后肠杆菌(7.98±0.12)lgCFU/g、酵母菌(8.86±0.38)lgCFU/g、双歧

杆菌(8.24±0.38)lgCFU/g均高于对照组的(7.65±0.16)、(8.52±0.29)、(7.68±0.42)lgCFU/g,差异有统计

学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。观察组复发率为3.33%,

低于对照组的20.00%,差异有统计学意义(P0.05)。结论改善老年胃溃疡患者的干预方式时,选择经

益生菌联合抗Hp方案治疗具有明显疗效,有助于改善患者的肠道菌群,减少溃疡复发。

【关键词】老年胃溃疡；抗幽门螺杆菌方案；益生菌；肠道菌群分布

DOI：10.14163/j.cnki.11-5547/r.2024.13.029

Studyonthefeasibilityofprobioticscombinedwithanti-Hpregimeninthetreatmentofelderlypatients

withgastriculceranditsinfluenceondistributionofgutmicrobiotaCHENMing,GUOXia.Departmentof

Gastroenterology,ChongyiCountyPeoplesHospital,Ganzhou341300,China

【Abstract】ObjectiveToexplorethefeasibilityofprobioticscombinedwithanti-Helicobacterpylori(Hp)

regimeninthetreatmentofelderlypatientswithgastriculceranditsinfluenceondistributionofgutmicrobiota.

Methods60elderlypatientswithgastriculcersweredividedintotheobservationgroupandthecontrolgroup

accordingtocomputerrandomgroupingmethod,with30casesineachgroup.Patientsintheobservationgroup

weretreatedwithprobioticscombinedwithanti-Hpregimen,whilepatientsinthecontrolgroupweretreated

withanti-Hpregimen.Thedistributionofgutmicrobiota,incidenceofadversereactions,andrecurrencerates

werecomparedbetweenthetwogroupsofpatients.ResultsBeforetreatment,therewasnosignificantdifference

inenterobacteriaceae,yeastandbifidobacteriumbetweenthetwogroups