小型猪听性脑干反应分析及脉冲噪声暴露后的变化 .pdfVIP

小型猪听性脑干反应分析及脉冲噪声暴露后的变化--第1页

小型猪听性脑干反应分析及脉冲噪声暴露后的变化

陈志婷;王方园;冀飞;杨仕明;吴南

【摘要】ObjectiveToinvestigatethecharacteristicsofauditorybrainstem

responses(ABRs)inhealthyminiaturepigsandtheirchangesafterimpulse

noiseexposure.MethodsHealthyminiaturepigswereexposedtoimpulse

noiseat30,50,80or100pulsesseparately,andauditorybrainstem

responsesweretestedbeforeandimmediately,at1,2,4and8weeksafter

exposure.Auditorybrainstemresponsecharacteristicsandchangesafter

noiseexposurewererecorded.ResultsABRwavesinhealthyminiature

pigsshowedfivetypicalpeaks,consistentwiththoseinotherspecies.The

meanthresholdofclick-ABRswas25±5dBSPL.Afterhighintensity

impulsenoiseexposure,theABRthresholdwassignificantlyincreased.No

identifiableABRwavescouldbedetectedimmediatelyafterexposureto

morethan50pulsesatthemaximumsystemoutput.ToneburstABR

thresholdsat4,8,16,20and32kHzalsoincreasedtohigherthan90dB

SPLimmediatelyafternoiseexposure.At1weekafterexposure,various

degreesofthresholdsrecoverywereobserved,constitutingmostrecovery

afternoiseexposure.Fromthesecondtotheeighthweek,threshold

recoverywasplateaued.RecoveryoftoneburstABRthresholdsat4,8,16,

20and32kHzwereconsistentwiththatofclickABR,withnostatistically

significantdifferencesnbsp;amongthefrequencies.Furthermore,ABR

wavesshowedpoordifferentiationasthetimewenton,despiterecovery

inthreshold.ConclusionsABRwavesinminiaturepigsaresimilartothose

小型猪听性脑干反应分析及脉冲噪声暴露后的变化--第1页

小型猪听性脑干反应分析及脉冲噪声暴露后的变化--第2页

ofrodentsandhumans,butaremoresensitivetoimpulsivenoise

exposurethaninrodents,albeitwithshorterrecoveryperiod.In