滤泡淋巴瘤的治疗策略.ppt

下载文档

0
0
约7.16万字
约 68页
2025-04-08 发布于广东
举报
版权申诉
保障服务

滤泡淋巴瘤的治疗策略.ppt

1、本文档共68页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

*EvolvingStandardsofCareinNon-HodgkinsLymphoma**VAIndolentLymphomav4*PhilipJ.Bierman,M.D.*CVP,cyclophosphamide,vincristine.prednisone;R,rituximab.?TheintroductionofrituximabhaschangedthewayfollicularlymphomasaswellasmostotherB-celllymphomasaretreated.Theadditionofrituximabtoprimarychemotherapyimprovessurvivalforpatientswithfollicularlymphoma.OnestudydemonstratingthisimprovementwasaninternationalmulticentertrialcomparingCVPwithR-CVPforfollicularlymphoma.Thistrialincludedpatientswithfollicularlymphomagrade3aswellasthosewithfollicularlymphomasgrade1and2.?Patientsreceived8cyclesofstandardCVPor8cyclesofCVPcombinedwithrituximab.?*********************CHOP,cyclophosphamide,doxorubicin,vincristine,prednisone;CR,completeresponse;CRu,unconfirmedcompleteresponse;CVP,cyclophosphamide,vincristine,prednisone;FCM,fludarabine,cyclophosphamide,mitoxantrone;FL,follicularlymphoma;PR,partialresponse;R,rituximab.?ThisquestionwasaddressedinthePRIMAtrialwithdatapresentedatthe2010AmericanSocietyofClinicalOncologyannualmeeting.Patientswithfollicularlymphoma,includingthosewithfollicularlymphomagrade3,weretreatedwitheitherR-CHOP,R-CVP,orrituximabwithafludarabine-containingregimenbasedonthephysician’schoice.Patientswhorespondedwererandomizedtoeitherobservationortorituximabmaintenancewith1doseevery8weeksfor2years.?Formoreinformation,goonlineto:/Oncology/Conference%20Coverage/Clin%20Onc%20June%202010/Tracks/Hematologic%20Malignancies/Capsules/8004.aspxEvolvingStandardsofCareinNon-HodgkinsLymphoma***CR,completeresponse;FL,follicularlymphoma;Maint,maintenance;Ph,phase;PR,partialresponse;QoL,qualityoflife;TTF,timetotreatmentfailure.RichardI.Fisher,MD:TheRESORTE4402trialisanimportantstudyaddressingtheroleof