文献1-3丙二醇工艺流程.docVIP

文献1,3丙二醇工艺流程

Englishanswer：

1,3-propanediol(1,3-PDO)isaversatileplatformchemicalthathasgainedsignificantattentioninrecentyearsduetoitspotentialuseintheproductionofbio-basedplastics,solvents,andpharmaceuticals.Theconventionalproductionof1,3-PDOinvolvesthechemicalsynthesisofpropyleneoxide(PO),whichisthenhydratedtoform1,3-PDO.However,thisprocessisenergy-intensiveandreliesonfossilfuel-basedfeedstocks.

Inrecentyears,therehasbeenincreasinginterestinthedevelopmentofsustainableandcost-effectivebio-basedroutesfortheproductionof1,3-PDO.Onepromisingapproachinvolvesthefermentationofglycerol,abyproductofthebiodieselindustry,bygeneticallyengineeredmicroorganisms.Thisprocesshasbeenextensivelystudied,andseveralmicroorganisms,includingEscherichiacoli,Klebsiellapneumoniae,andBacillussubtilis,havebeenshowntobecapableofproducing1,3-PDOfromglycerol.

Theoverallprocessflowforthebio-basedproductionof1,3-PDOfromglycerolcanbesummarizedasfollows:

1.Pretreatmentofglycerol:Theinitialstepinvolvesthepurificationandpretreatmentofglyceroltoremoveimpuritiesandprepareitforfermentation.Thismayinvolvefiltration,centrifugation,and/orchemicaltreatment.

2.Fermentation:Thepretreatedglycerolisthenfermentedbygeneticallyengineeredmicroorganismsthathavebeenengineeredtoproduce1,3-PDO.Thefermentationprocessistypicallycarriedoutinafed-batchorcontinuousbioreactorundercontrolledconditionsoftemperature,pH,andoxygensupply.

3.Downstreamprocessing:Afterfermentation,thebrothcontaining1,3-PDOissubjectedtodownstreamprocessingstepstorecoverandpurifytheproduct.Thismayinvolvecentrifugation,filtration,and/ordistillation.

Thebio-basedproductionof1,3-PDOfromglyceroloffersseveraladvantagesovertheconventionalchemicalsynthesisroute.Firstly,