CA125、SCC、SOX2-Ab联合检测对早期肺癌诊断的临.docx

CA125、SCC、SOX2-Ab联合检测对早期肺癌诊断的临床价值研究

田佳李震陈云浩刘英超

[关键词]?肺癌；糖类抗原125；鳞状上皮细胞癌抗原；性别决定区Y框蛋白2自身抗体；诊断价值

[中图分类号]?R446??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.06.003

Clinical?value?of?combined?detection?of?CA125，?SCC?and?SOX2-Ab?in?the?diagnosis?of?early?lung?cancer

TIAN?Jia1，?LI?Zhen2，?CHEN?Yunhao2，?LIU?Yingchao2

1.Department?of?Pathology，?the?Second?Peoples?Hospital?of?Liaocheng，?Linqing?252600，?Shandong，?China;?2.Department?of?Clinical?Laboratory，?the?Second?Peoples?Hospital?of?Liaocheng，?Linqing?252600，?Shandong，?China

[Abstract]?Objective?To?investigate?the?clinical?value?of?combined?detection?of?carbohydrate?antigen?125?（CA125），?squamous?cell?carcinoma?antigen?（SCC）?and?Sox2?autoantibodies?（SOX2-Ab）?in?the?diagnosis?of?early?lung?cancer.?Methods?50?healthy?persons，?50?patients?with?benign?pulmonary?nodules?and?50?patients?with?lung?cancer?were?selected?from?July?2020?to?June?2021，?as?physical?examination?group，?benign?pulmonary?nodules?group?and?lung?cancer?group?respectively.?The?serum?levels?of?CA125?and?SCC?were?measured?by?chemiluminescence?analyzer?and?its?related?reagents，?and?the?protein?content?of?SOX2-Ab?was?determined?by?enzyme?linked?immunosorbent?assay.?The?receiver?operating?characteristic?curve?was?calculated.?Results?The?expression?levels?of?CA125，?SCC?and?SOX2-Ab?in?lung?cancer?group?were?38.50?（22.75，?51.25）?U/ml，?3.08?（1.40，?3.60）?ng/ml，?13.45?（10.80，?15.43）?ng/ml，?respectively.?The?sensitivity，?specificity?and?accuracy?of?combined?detection?of?CA125，?SCC?and?SOX2-Ab?for?early?lung?cancer?were?91%，?61%?and?86%，?respectively.?Conclusion?The?combined?detection?of?CA125，?SCC?and?SOX2-Ab?protein?is?sensitive?to?the?diagnosis?of?early?lung?cancer，?and?can?be?used?as?a?detection?scheme?for?early?lung?cancer.

[Key?words]?Lung?cancer;?CA125;?SCC;?SOX2-Ab;?Diagnostic?value

1??资料与方法

1.1??一般资料

1.2??纳入及排除标准

纳入标准：①肺癌患者病理诊断明确；②未进行放化疗或免疫治疗；③临床资料齐全；④自愿参与本研究并签署知情同意书。排除标准：①合并严重肝、肾功能异常者；②合并其他肺部疾病者（如肺炎）；③合并其他疾病者。

1.3??CA125、SCC、SOX2-Ab蛋白检测

抽取三组受试者的空腹静脉