脑小血管病总负荷与急性脑梗死患者早期预后的相关性.docxVIP

脑小血管病总负荷与急性脑梗死患者早期预后的相关性.docx

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脑小血管病总负荷与急性脑梗死患者早期预后的相关性

贾小丹曲娟

[中图分类号]?R743????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.03.007

Correlation?between?total?burden?of?cerebral?small?vessel?disease?and?early?prognosis?in?patients?with?acute?cerebral?infarction

JIA?Xiaodan1,2,?QU?Juan3

1.Graduate?School?of?Bengbu?Medical?College,?Bengbu?233030,?Anhui,?China;?2.Department?of?Neurology,?the?First?People’s?Hospital?of?Jiashan?County,?Jiaxing?314000,?Zhejiang,?China;?3.Department?of?Neurology,?the?First?Hospital?of?Jiaxing,?Jiaxing?314000,?Zhejiang,?China

[Abstract]?Objective?To?investigate?the?correlation?between?the?total?load?of?cerebral?small?vessel?disease?(CSVD)?and?the?early?prognosis?of?patients?with?acute?cerebral?infarction?(ACI).?Methods?A?total?of?150?patients?with?ACI?admitted?to?the?Department?of?Neurology,?the?First?Hospitalnbsp;of?Jiaxing?from?October?2020?to?June?2022?were?included,?accordingnbsp;to?modified?Rankin?scale?(mRs)?score,?patients?were?classified?good?prognosis?group?(mRs≤2?points)?and?poor?prognosis?group?(mRs≥3?points),?baseline?data?and?clinical?characteristics?were?compared?between?the?2?groups,?and?total?CSVD?load?was?assessed?by?cranial?MRI,?single?factor?and?multi-factor?analysis?were?performed?with?Logistic?model.?The?relativity?of?CSVD?load?and?early?prognosis?was?analyzed?with?Pearson?method.?Results?Age,?length?of?stay,?National?Institute?of?Health?stroke?scale?(NIHSS),?hypersensitivity?C-reactive?protein,?triglyceride?and?homocysteine?were?significantly?higher?in?poor?prognosis?group?than?those?in?good?prognosis?group,?the?difference?was?significant?(P0.05).?The?scores?of?lacunar,?cerebral?microhemorrhage,?white?matter?hyperintensity?and?CSVD?in?poor?prognosis?group?were?significantly?higher?than?those?in?good?prognosis?group?(P0.05).?Multivariate?Logistic?regression?analysis?showed?that?length?of?stay?(OR=1.278,?95%CI=1.054?1.548,?P=0.012),?admission?NIHSS?score?(OR=1.354,?95%CI=1.113?1.647,?P=0.002),?CSVD?total?load?(OR=2.494,?95%CI=1.666?3.735,?P0.001)?w

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