外周血炎症指标对初诊多发性骨髓瘤患者预后的预测价值.docx

外周血炎症指标对初诊多发性骨髓瘤患者预后的预测价值

黄宵莓黄柏明黄训俊吴菁李若林

[关键词]?多发性骨髓瘤；炎症指标；中性粒细胞与淋巴细胞比值；单核细胞与淋巴细胞比值；血小板与淋巴细胞比值；预后

[中图分类号]?R733.3????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.02.004

Predictive?value?of?peripheral?blood?inflammatory?indicators?in?patients?with?new-diagnosed?multiple?myeloma

HUANG?Xiaomei1，?HUANG?Boming2，?HUANG?Xunjun3，?WU?Jing4，?LI?Ruolin4

1.Department?of?Clinical?Laboratory，?the?First?Affiliated?Hospital?of?Guangxi?Medical?University，?Nanning?530021，?Guangxi，?China;?2.Department?of?Clinical?Laboratory，?the?People’s?Hospital?of?Baise，?Baise?533000，?Guangxi，?China;?3.Department?of?Hematology，?the?People’s?Hospital?of?Baise，?Baise?533000，?Guangxi，?China;?4.Clinical?Medical?Experiment?Center，?the?First?Affiliated?Hospital?of?Guangxi?Medical?University，?Nanning?530021，?Guangxi，?China

[Abstract]?Objective?To?explore?the?predictive?value?of?peripheral?blood?inflammatory?indicators?such?as?neutrophil-to-?lymphocyte?ratio?（NLR），?monocyte-to-lymphocyte?ratio?（MLR）?and?platelet-to-lymphocyte?ratio?（PLR）?on?the?prognosis?of?patients?with?primary?diagnosis?of?multiple?myeloma?（MM）.?Methods?Using?a?retrospective?method，?77?patients?with?first?diagnosis?of?MM?admitted?to?the?Department?of?Hematology?of?Baise?People’s?Hospital?and?77?healthy?medical?checkups?with?peripheral?blood?NLR，?MLR?and?PLR?were?collected?and?compared?the?differences.?Then?the?patients?with?primary?diagnosis?of?MM?were?categorized?into?high?NLR?group，?low?NLR?group，?high?MLR?group，?low?MLR?group，?high?PLR?group，?low?PLR?group?using?the?mean?value?as?the?critical?value，?and?the?prognosis?of?the?patients?in?each?group?as?well?as?the?relationship?with?overall?survival?time?（OS）?were?compared.?Results?The?NLR，?MLR，?and?PLR?of?patients?with?initial?diagnosis?of?MM?were?significantly?higher?than?those?of?healthy?controls，?and?the?differences?were?statistically?significant?（all?P0.05）.?Serum?β2-microglobulin?（β2-MG）?levels?were?higher?in?patients?with?high?NLR?and?high?MLR?than?in?the?low?NLR?and?low?MLR