眼底血管改变与脑白质高信号的相关性分析.docx

眼底血管改变与脑白质高信号的相关性分析

花金萍徐博伦詹建梅熊俊峰童毓华

[关键词]?光学相干断层扫描；光学相干断层扫描血管成像；假定血管源性脑白质高信号；视网膜血流；视网膜神经纤维层

[中图分类号]?R816.97；R770.43??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.06.011

Correlation?analysis?between?retinal?vascular?changes?and?white?matter?hyperintensity

HUA?Jinping1，?XU?Bolun2，?ZHAN?Jianmei3，?XIONG?Junfeng4，?TONG?Yuhua2

1.The?Second?Clinical?Medical?College，?Zhejiang?Chineese?Medicine?University，?Hangzhou?310000，?Zhejiang，?China;?2.Department?of?Ophthalmolog，?Quzhou?Peoples?Hospital，?Quzhou?324000，?Zhejiang，?China;?3.Department?of?Neurology，?Quzhou?Peoples?Hospital，?Quzhou?324000，?Zhejiang，?China;?4.Department?of?Radiology，?Quzhou?Peoples?Hospital，?Quzhou?324000，?Zhejiang，?China

[Abstract]?Objective?To?investigate?the?correlation?between?retinal?vascular?changes?and?patients?with?white?matter?hyperintensity?（WMH）.?Methods?A?total?of?87?patients?diagnosed?with?WMH?in?the?Department?of?Neurology，?Quzhou?Peoples?Hospital，?from?July?2022?to?July?2023?were?selected?as?experimental?group.?Concurrently，?80?age-matched?healthy?individuals?without?WMH?undergoing?regular?health?check-ups?were?randomly?selected?as?control?group.?Optical?coherence?tomography?（OCT）?and?optical?coherence?tomography?angiography?（OCTA）?technologies?were?applied?to?measure?retinal?vascular?parameters，?including?vascular?structure，?microvascular?density，?and?retinal?nerve?fiber?layer?（RNFL）?thickness.?Compare?the?differences?between?two?groups?and?analyze?their?correlation.?Results?Compared?with?the?control?group，?the?experimental?group?exhibited?no?correlation?between?retinal?vascular?structure?and?microvascular?density?parameters?with?WMH.?However，?there?was?a?significant?decrease?in?average，?temporal?upper，?and?nasal?lower?RNFL?thickness?（P0.05）.?Conclusion?OCT?and?OCTA?are?feasible?methods?for?detecting?WMH，?and?the?thickness?of?the?temporal?upper?and?nasal?lower?retinal?nerve?fiber?layers?can?serve?as?indicators?for?predicting?the?risk?of?WMH?occurrence.

[Key?words]?Optical?